Morning Lectures (password required)
Discussion Points
Thursday April 3
- FDG Uptake time: 60 minutes, 90 minutes , 2 hours or beyond, best overall compromise, any cancers for which extended uptake time should be routine
- Patient activity during and before the FDG uptake period, when is it OK for people to get up and around after FDG infusion for body oncology studies
- Should everyone get a sedative or anxiolytic, or which particular patients
- Does an all protein diet the day before the scan really suppress heart uptake
- Special instructions for head & neck cancer patients (no talking/swallowing), when before and after FDG infusion
- IV for injecting FDG, should an IV always be placed
- Same IV or different IV for contrast
- When to give the oral contrast, how to get uniform opacification
- Getting patients to hold still during the scan, should restraints be used
- Dealing with diabetics, fasting, insulin, ect.
- Patients on insulin pumps
- Brown fat uptake. Warm room, warm blankets, anxiolytics vs beta blockers
- Hydration: oral vs IV, how much
- Hydration/Lasix for getting urinary tracer activity down
- PET imaging time per bed position for body studies vs neck
- Matrix for body vs neck (128 vs 256) PET acquisition
- Crainocaudad vs caudocranial PET acquisition for different disease indications
- dual time point for lung nodules vs extrapulmonary findings
- dual time point vs routine long uptake time
- Breath holding for small pulmonary nodules. Do you really need a full inspiration breath hold or is an on-the-fly mid expiratory breath hold OK on current 16+ CTs
- If you need a full inspiration breath hold, for which cancers (for lung cancer, sarcomas, rectal but not lymphoma, for example)
- Is quiet breathing OK, on 16 to 64 slice CT for say, lymphoma
- Should arms be up as much as possible
- How much beam current do you really need for the lungs, how much detail of the pulmonary markings need to be seen. Is under 200 mA OK, under 100 mA and how does this relate to determining if a pulmonary nodule is speculated, detecting fat planes, ect.
- If lymph node size is important in staging (that is if the node is enlarged even if it is not abnormal on the PET images, it is still suspicious), then do you need IV contrast to properly assess lymph node size in the mediastinum, the hila. Does T-staging lung, esophageal, breast, require IV contrast
- For restaging is lymph node size important, necrosis, extanodal spread, and is IV contrast important here as well
- Bronchoavelolar carcinoma: how much image quality to characterize, is breath hold required
- Slice thickness of images for the lungs
- Is interstitial spread of tumor really an issue requiring high detail lung images
- Should there always be lung algorithm recon images made, not just soft tissue algo
- if a separate breath hold acquisition is performed, should this be precontrast or during arterial phase
- IV contrast abdomen and pelvis- but how much and what phases. Is portal venous phase enough. Any need for 3 minute delay scans through kidneys
- What diseases should a late arterial phase be added to a portal venous phase
- How much beam current is needed for abdomen, esp in light of detecting small liver lesions, seeing peritoneal carcinomatosis, peritoneal implants, ect
- Should the entire colon be entirely opacified with positive oral contrast, any diseases in which this should be the case colon
- Negative oral contrast, does it require IV to work best
- Efforts to reduce bladder tracer activity: catheter vs hydration with Lasix, which diseases should reduction of bladder tracer activity be routine
- Recon slice thickness for Abdomen and Pelvis (noise vs slice thickness vs detail)
- Breath hold for the abdomen and pelvis, is on the fly mid expiratory OK or do you really need a full expiratory breath hold
- Any special recons other than soft tissue algorithm
- For dedicated head & neck PET/CT, how sharp do the CT images have to be, as sharp as a CT alone, how much beam current should be used
- IV contrast: should this be used always for staging, for restaging
- Bolus timing for IV contrast, best way to insure venous and arterial opacification
- how important is tumor blush from IV contrast in determining T stage in head and neck, should the amount of IV contrast used be based on getting good pathologic tumor blush
- how important is IV contrast in assessing extranodal spread in head and neck
- Slice thickness reconstruction and image recon algorithm for neck
- Preferred window and level settings for reviewing CT part of PET/CT with neck
- Proper head position for head & neck cancer PET/CT acquisition
- What to do about tooth amalgam artifact. Scan twice with different head positions?
- Difference between and dedicated neck CT acquisition and neck as part of a whole torso exam, that is, what is acceptable CT technique with say routine lymphoma vs primary head and neck cancer (CT zoom, head positioning, arms up vs down, ect)
- When can you scan just the neck and when do you add on an additional chest or whole torso PET/CT for a primary head & neck cancer (squamous vs other cell types)
- Positive oral contrast: thin barium vs water soluble, which preferred for which patients
- Density and distribution problems with oral contrast, how do you get uniform opacification in small bowel since you have captive patient for 60+ minutes
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- Negative oral contrast, does it work better with IV contrast
- Positive vs negative oral contrast in thin people with no internal fat
- Rectal contrast-which situations should it be used
- Stomach, should it be distended with contrast or water routinely
- Total IV contrast load (volume and iodine content) when doing a torso scan, dedicated head & neck acquisition
- When is too much IV contrast enhancement
- IV contrast infusion rates. When to do rates higher than 3 ml/sec
- Contrast enhanced CT for attenuation correction. Can this be used routinely and would problems be expected at high (4 or 5 ml/sec) infusion rates
- Eliminating venous contrast related artifacts in the infusion route deep veins, saline chase vs caudocranial scan
- Chasing the contrast bolus: methods to maintain equal venous and arterial opacification over entire torso scanned
- Would it be helpful to have the contrast injector integrated into the PET/CT operating system, or is a separate unit not too much trouble
- are there different work flow schemes such as doing the image archiving at the end of the day? Is PACS make things easier or harder
- how important is image recon time, does that really gum things up if it is slow
- is FDG uptake time get in the way, so even if we want to go longer it gums things up
- table and restraint devices needed of RT planning scans
- lasers for positioning, do you really need them
- scanner gantry width, is more really needed, how wide would be enough
- scanning protocols, do the RT folks want things different in terms of image quality and use of contrast
- respiratory gating, a necessity-for which type of RT planning is gating needed
- image recon formats needed for RT planning
- feature that would facilitate moving images from PET/CT to the RT planning software
- how RT planning scans change work flow and timing
- coordinating patient throughput in a busy center and the nature of ancillary individuals (assistants, nurses, ect) needed to help. What sort of things from industry (scanners, FDG suppliers) would help make thing better and more efficient
- dual time point or high count scanning, changes in work flow design to accommodate
- are there different work flow schemes such as doing the image archiving at the end of the day? Is PACS make things easier or harder?
- how important is image recon time, does that really complicate throughput and work efficiency if image recon time is long. How long is too long for image recon time
- is FDG uptake time get in the way, even if you have enough uptake rooms, by requiring extended patient monitoring
- monitoring devices in scanners needed to improve patient safety and work efficiency
- coordinating patient throughput, including interview, injection, uptake period management, scan, post scan management.
- what are the roles of the technologist vs some things others could be doing to help out, roughly how many technologists and ancillary personnel do you need per scanner
Friday April 4
Axial Coverage on PET/CT
Is there greater axial coverage than really needed due to the PET/CT CT code descriptors?
What should axial coverage be for the following cancers:
- Lung cancer staging and restaging
- Solitary pulmonary nodule
- Esophageal cancer staging and restaging
- Breast cancer staging and restaging
- Colorectal cancer staging and restaging
- Gyn cancer staging and restaging
- Lymphoma staging and restagng
- Head & Neck cancer (should lungs/torso always be included)
- Melanoma (head to toe vs head, neck and torso)
PET/CT Protocols for Therapy Monitoring
Should therapy monitoring protocol be different form staging and restaging in terms of axial coverage, PET acquisition and CT parameters?
is CT needed at all, do we expect morphologic changes after 2 cycles of chemotherapy?
should the CT parameters be the same as the staging/restaging CT or just a true transmission scan?
should the PET acquisition parameters be the same as staging and restaging
should special procedures be used to insure standard and reproducible SUVs?
Assessing FDG Uptake and SUVs
Are SUVs currently really standardized at all, and should they be relied upon for diagnostic decisions such as pulmonary nodes, nodes, ect?
isn’t qualitative assessment of normal vs abnormal easier, faster and more foolproof?
should visual assessment on MIP images really be the standard for diagnosis?
what things are making SUVs not standard such as dose extrav and incomplete dose administration, different scanners, uptake times, differing image reconstruction methods, serum glucose considerations?
are the SUVs people are getting now higher than in the 1990s and why?
any method available to check the SUV numbers to see if they make sense?
since different iterative methods and number of iterations change SUV value considerably for small lesions, should filtered back projection reconstruction by the standard for measuring SUVs?
anything manufacturers can do to help put some S into the SUVs?
Pediatric and Dosimetry Issues
What are the important differences in a Pediatric PET/CT protocol vs adult?
Dose from CT and PET for an adult vs child at different beam currents and FDG doses.
How do you reduce the dose from the CT (kVp and mA, beam current modulation).
How do you reduce the dose from the PET (FDG dose parameters)?
PET acquisition in kids, anything different than adults (shorter emission times)?
should oral and IV contrast be used routinely to make up for the low image contrast due to the reduced CT beam current?
positive vs negative oral contrast in kids (not a lot of internal fat usually).
CT slice thickness and recon algo in kids, any different than adults
sedation issues with kids
positioning in scanner-arms up vs arms down with kids
PET and CT Image Reconstruction
how long should iterative and related higher end PET reconstruction take before it interferes with workflow?
is truncation artifact a problem, should gantry size be increased?
SUVs and iterative methods, should we just use filtered back projection, or are scatter and other correction method differences between vendors confounding anyway?
Workflow Issues
what are the key limitations in workflow in image reconstruction and archiving?
what can the manufacturers do to improve workflow?
how can ancillary personnel be used to improve workflow and efficiency
PACS and RAIDS
how long should raw data be saved?
PET/CT Interpretation, Interpretative Workload and Reporting
how much of the interpretative workload is PET vs CT?
should CT and PET findings be integrated in the report, or is hot spot localization adequate?
should CT findings always be included the PET/CT report regardless of CT protocol?
is there such a thing as “CT performed for anatomic localization purposes only?
should size measurements be included in reports, SUVs?
should TNM staging be given?
what key things do referring physicians want in a PET/CT report
what CT or PET findings need to be reported directly to the referring clinician?
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